ABP-7 (10mg)

ABP-7 (actin binding peptide-7) is a heptapeptide made of seven amino acids, which bears the sequence Acetyl-LKKTETQ. This peptide appears to be an N-acylated 17-23 fragment from a bigger molecule, Thymosin Beta 4. Consequently, this fragment is also sometimes termed a TB-500 Fragment.

ABP-7 is a synthetic peptide, produced via solid-phase peptide synthesis.(1) Some researchers consider its LKKTETQ sequence to be the central actin-binding domain in Thymosin Beta 4. Therefore, ABP-7 is expected to have similar potential actions regarding actin binding, as its Thymosin Beta 4 counterpart.(2) Thymosin Beta 4 is posited to function as an actin-binding protein, particularly through its domain ABP-7. This domain notably inhibits the polymerization of globular actin (G-actin) into filamentous actin (F-actin), a process termed actin sequestration. This inhibition may result in elevated levels of G-actin within the cell.

Actin, a pivotal component of the cellular cytoskeleton, is considered to not only provide structural integrity but may also play an essential role in various cellular activities, including cell motility and shape alteration. The mechanism by which ABP-7 may potentially prevent the polymerization of G-actin into F-actin appears to involve the stabilization of actin in its monomeric form, thereby limiting its availability to form the polymeric filaments necessary for a functional cytoskeleton. This alteration in the cytoskeletal architecture may impact the cell’s ability to migrate and adapt its shape, which are considered to be critical functions in numerous biological processes.

For instance, studies in wound healing and tissue regeneration suggest that cell motility may enable cells to move into and populate damaged areas to facilitate repair and restoration. Moreover, the possible disruption of actin polymerization by ABP-7 may influence other cellular mechanisms tied to actin dynamics, including intracellular transport and signal transduction pathways that rely on the actin cytoskeleton. The broader implications of these actions suggest that ABP-7’s potential role in modulating actin polymerization could be significant in understanding and potentially manipulating cellular behaviors.

Chemical Makeup:
Molecular Formula: C38H81N9O20
Molecular Weight: 889.5 g/mol
Other Known Titles: TB-500 Fragment, Ac-LKKTETQ

ABP-7 peptide is available for research and laboratory purposes only. Please review our Terms and Conditions before ordering.